Slaughterhouse Five A Warning Against War Essay - 1716 Words

Kurt Vonneguts novel Slaughterhouse-Five; or The Childrens Crusade: A Duty-Dance with Death is, as suggested by the title, a novel describing a crusade that stretches beyond the faint boundaries of fiction and crosses over into the depths of defogged reality. This satirical, anti-war piece of literature aims to expose, broadcast and even taunt human ideals that support war and challenge them in light of their folly. However, the reality of war, the destruction, affliction and trauma it encompasses, can only be humanly described by the word â€Å"war† itself. Furthermore, oftentimes this term can only be truly understood by those who have experienced it firsthand. Therefore, in order to explain the unexplainable and humanize one of the most†¦show more content†¦On his feet were cheap, low-cut civilian shoes which he had bought for his fathers funeral. Billy had lost a heel, which made him bob up-and-down, up-and-down. The involuntary dancing, up-and-down, up-and-down, made his hip joints sore. ... He didnt look like a soldier at all. He looked like a filthy flamingo. (33) With this description, Vonnegut vastly distances Billy from the ideal, strong and mighty image of a soldier, yet Billy is a soldier nonetheless. Not only is this weak and ungracious character fighting and representing the honour of his country but also he is one of the few soldiers who survive the war; he outlives many of the other soldiers that could be considered better suited for war. Furthermore, Vonnegut compares Billy to a filthy flamingo, highlighting the distance that exists between societys soldier ideal, graceful and admirable, and the soldiers reality, harsh and rampageous. In short, Billy is so far from what is expected that he â€Å"shouldnt even be in the Army† (51). However, Billy is not the only soldier in this ludicrous predicament. Vonnegut describes the entire Army as chaotic, confused and ludicrous: The eight ridiculous Dresdeners ascertained that these hundred ridiculous creatures really were American fighting men fresh from the front. They smiled, and then they laughed. Their terror evaporated. There was nothing to be afraid of. Here were more crippled human beings, more fools like themselves. Here was lightShow MoreRelatedWelcome to the Monkey House, Harrison Bergeron, and Slaughterhouse-five, by Kurt Vonnegut1233 Words   |  5 Pageslambasted in his works. Vonnegut’s experience as a soldier in WWII during firebombing of Dresden corrupted his mind and enabled him to express the chaotic reality of war, violence, obsession, sex and government in a raw and personal manner. Through three works specifically, â€Å"Welcome to the Monkey House,† â€Å"Harrison Bergeron,† and Slaughterhouse-five, one can see ties to all the chaotic elements of Vonnegut’s life that he routinely satirized. One can also see how Vonnegut’s personal experiences created hisRead MoreSlaughterhouse Five By Kurt Vonnegut Essay1560 Words   |  7 Pagesthe war are found to suffer some sort of psychological issue (NBC). One of these soldiers is Kurt Vonnegut. Vonnegut grew up in Illinois where his family would eventually lose all their money along with his mother (notable biographies). After attending Cornell University Vonnegut enlisted into World War II. His experiences in World War II shaped his anti-war novel Slaughterhouse-Five. Slaughterhouse-Five was published â€Å"during the peak of protest against American involvement in the Vietnam war† (NotableRead MoreSlaughterhouse Five Literary Analysis890 Words   |  4 PagesSimilarly, Kurt Vonnegut’s Slaughterhouse-Five explores this struggle between free-will and destiny, and illustrates the idea of time in order to demonstrate that there is no free-will in war; it is just destiny. Vonnegut conveys this through irony, symbolism and satire. Time concept is a complex idea that resist full understanding thus we can only percept it and determinism is a belief that is adopted by whose can percept time better than the others. In Slaughterhouse-Five, Billy Pilgrim is kidnappedRead MoreKurt Vonnegut s Slaughterhouse Five 1490 Words   |  6 Pagespublished a variety of works including novels, short stories, plays, and a few works of non-fiction. Kurt Vonnegut explains how war and the experiences that come with it can cause suffering to the minds of people that it affects. In his novel Slaughterhouse-Five, Kurt Vonnegut uses his novel to focus on his anti-war stance by showcasing humanity s suffering due to war. Vonnegut reveals this suffering through Billy Pilgrim s experience with the bombing of Dresden, his development of schizophreniaRead MoreThe Childrens Crusade: Innocence, Masculinity, and Humanity1440 Words   |  6 Pages　　Are wars still being fought by children. One could argue â€Å"no†, but others will say â€Å"yes†. Men go into war everyday, but many are not even fully grown. In Kurt Vonneguts Slaughterhouse-Five, he uses some of his own personal experiences to show the realities of war by examples of innocence, masculinity, and humanity through his main character Billy Pilgrim. Billy can supposedly time travel after being kidnapped by aliens from Tralfamadore and uses it to travel to his time in WWII were he experiencedRead MoreSlaughterhouse Five By Kurt Vonnegut860 Words   |  4 PagesThroughout the course of the novel Slaughterhouse Five by Kurt Vonnegut, the reader is walked through the morbid but engaging life of Billy Pilgrim, a character who experiences many dreadful tragedies such as war. The way Vonnegut structures this novel is scattered and not told chronologically because we experience Billy Pilgrim’s life just as he does without suspense or logical order. Shortly after Pilgrim going to war in 1944 he becomes â€Å"unstuck in time† which simply means that he experiences differentRead MoreSlaughterhouse Five By Kurt Vonnegut915 Words   |  4 Pages Slaughterhouse Five by Kurt Vonnegut takes places on two contrasting planets. One is Earth, where war tears apart families and minds, and the other is Tralfamadore, where supernatural alien beings share their extended knowledge of the world. Vonnegut uses the two planets, Earth and Tralfamadore, to show the contrasting ideas of chaos and order, and that human actions have limitations that render them helpless against a meaningless universe. In Slaughterhouse Five, Earth is a grim, war torn placeRead More Kurt Vonnegut’s Slaughterhouse-Five Essays3848 Words   |  16 PagesKurt Vonnegut’s Slaughterhouse-Five Great artists have the ability to step back from society and see the absurd circus that their world has become. Such satirists use their creative work to reveal the comic elements of an absurd world and incite a change in society; examples include Stanley Kubrick’s film, Dr. Strangelove, and Joseph Heller’s novel, Catch-22. Both works rose above their more serious counterparts to capture the critical voice of a generation dissatisfied with a nation ofRead MoreChanges Since the Sixties916 Words   |  4 Pagesthe schools. There were no grouchy warning labels on the records and no ratings necessary on the movies. And TV shows were acceptable to the whole family. Those were the sixties or at least part of it. Some of the 52 million sixties boomers called it the decade of peace, harmony and love mainly for the movement for peace and the flower power attitude. Others, a little more pessimistic, called it the decade of dissatisfaction because of the protests against the war and the race riots in many citiesRead More Changes Since The Sixties Essay878 Words   |  4 Pagesthe schools. There were no grouchy warning labels on the records and no ratings necessary on the movies. And TV shows were acceptable to the whole family. Those were the sixties or at least part of it. Some of the 52 million sixties’ boomers called it the decade of peace, harmony and love mainly for the movement for peace and the â€Å"flower power† attitude. Others, a little more pessimistic, called it the decade of dissatisfaction because of the protests against the war and the race riots in many cities

Essay on Divine Intellect in Dantes Inferno - 1903 Words

Divine Intellect in Dantes Inferno In Canto XI of Dantes Inferno, Virgil carefully explains the layout of hell to his student, Dante. Toward the end of his speech, Virgil says that Sodom and Cahors are speak[ing] in passionate contempt of God, (XI, 50-51), and divine will thus relegates them to the seventh circle. The sin of the Sodomites is clear for Dante, who poses no question on the matter, sodomy perhaps being an obvious affront to God which the bible directly addresses. However, the sin of Cahors, namely usury, is not clear to Dante. He asks Virgil to unravel the knot in his mind, since there is no obvious reason why a usurer - a money lender essentially - deserves any punishment at all for a crime†¦show more content†¦Thus, Dante is on Virgils level in one sense, and far below him in another, which is true in the grand scheme of the work: Dante is only beginning to understand the workings of the divine order by Canto XI, while Virgil borders on omniscience throughout. Furthermore, Dante has not yet eclipsed Virgil as a poet, since at this point the Inferno is hardly begun, while the Aeneid presents Virgils view of Hades from top to bottom.. In Dantes hell specifically, the reason that usury is a deadly sin is very confusing, which is why Dante calls it a knot. Unlike other sins, usury is not on its face a dreadful immorality. Virgil approaches the issue at first philosophically, making the profoundly esoteric claim that nature follows... the Divine Intellect and the Divine Art. The idea nature is therefore composed of these two abstract elements. The Intellect, coming first, must be at the root of the Art, since intellect must precede production, as in the Platonic doctrine of the essence of a thing preceding the existence of a thing. The Intellect is the potential; the art is the result. In concrete terms, the Intellect must therefore be the primordial stuff from which everything is made, and the Art therefore must be the process of making it into something tangible or usable. From this, then, we can deduceShow MoreRelatedDante s Divine Comedy : An Allegory Representative Of The Christian Soul974 Words   |   4 Pagesbad. Dante Aghileri, a poet who stars in his Divine Comedy as a pilgrim, finds himself lost in a dark wood. Though he sees a safe path to the light and out of the wood, he is forced to take an alternate route through an even darker place. The Divine Comedy is an allegory representative of the Christian soul. As the ending is bright and hopeful for Dante, Aghileri spreads that the ending for even the most sinful Christians can be as hopeful as dante’s, provided that they take the steps needed to achieveRead More Divine Comedy – Pagans in Paradise1474 Words   |  6 PagesDivine Comedy – Pagans in Paradise In the beginning when God created humanity, it was said that He created all humans in His image of goodness (Genesis 1:27). Dante then adds in his Divine Comedy that God has instilled a certain predetermined capacity of goodness in each human being as He wills, which should be utilized fully during life (Paradise 3:84). It would then be assumed, in Dantean thought, that all humans have the choice to live fully to this capacity and assume a place in heaven uponRead MoreDante And The Nature Of Sin967 Words   |  4 Pageshimself the main character in his Divine Comedy, finds himself lost in a dark wood at the start of The Inferno. Though he sees a safe path out of the wood towards an alluring light, he is forced to take an alternate route through an even darker place. As the ending of the pilgrim Dante’s voyage is bright and hopeful, Alighieri the poet aims to encourage even the most sinful Christians to hope for a successful end. Thus, Dante the pilgrim goes to hell in The Inf erno to better understand the nature ofRead MoreEssay on The Allegory of the Cave and Dante1251 Words   |  6 Pagesthe poet Dante Alighieri, writer of The Inferno in the 1300s, because it asserts the need to establish oneself as a contributor to society. Indeed, Dante’s work contributes much to Renaissance Italy as his work is the first of its scope and size to be written in the vernacular. Due to its readability and availability, The Inferno is a nationalistic symbol. With this widespread availability also comes a certain social responsibility; even though Dante’s audience would have been familiar with theRead MoreThe Importance Of Love In Dante Alighieris The Divine Comedy1291 Words   |  6 PagesIn Dante Alighieri’s poem, The Divine Comedy, Dante’s quest to find Beatrice symbolizes the importance of allowing love to be ones guide to divine understanding, for this is the only action which is completely controlled by God. Dante argues that altho ugh we have desires for sinful actions, humans have the ability to control these desires and decide our own fate. Furthermore, he argues that even if humans commit sin in life, if they will redemption before being sent to hell, they have the opportunityRead MoreDante’s Inferno in Milton ´s Paradise Lost1326 Words   |  6 PagesMany arguments have been made that Dante’s Inferno glimmers through here and there in Milton’s Paradise Lost. While at first glance the two poems seem quite drastically different in their portrayal of Hell, but scholars have made arguments that influence from Dante shines through Milton’s work as well as arguments refuting these claims. All of these arguments have their own merit and while there are instances where a Dantean influence can be seen throughout Paradise Lost, Milton’s progression ofRead MoreInferno And The Divine Comedy1834 Words   |  8 PagesInferno (c. 1314) serves as the first part of Dante Alighieriâ⠂¬â„¢s poem Divine Comedy which is a journey through Hell, Purgatory, and Heaven. On a broader level, Divine Comedy serves as an allegory for the journey of the soul towards God through the created earth. Inferno and the Divine Comedy serve as a form of scholastic thought, the rational study of religion, as Dante draws on medieval theology to share the modern view on God and the afterlife. This essay explores Dante’s perception of the universeRead MoreSatan in Paradaise Lost and Dantes Inferno1138 Words   |  5 Pageslove. The key differences between the two Hells is how the effect of the absence of God is created. For Milton is this is as mentioned created by the darkness and for Dante the effect is created with a cold, a cold wherein love cannot be sustained. Dantes other element of smell offers the smell unrested death, as the act of putrefaction is generally associated with crime scenes and criminal investigations. As well, the dominions of Hell have a different master in the two works. Milton has givenRead More The Weakness of Human Nature in Dantes Inferno Essay2203 Words   |  9 PagesDantes Inferno is full of themes. But the most frequent is that of the weakness of human nature. Dantes descent into hell is initially so that Dante can see how he can better live his life, free of weaknesses that may ultimately be his ticket to hell. Through the first ten cantos, Dante portrays how each level of his hell is a manifestation of human weakness and a loss of hope, which ultimately Dante uses to purge and learn from. Dante, himself, is about to fall into the weaknesses of humansRead MoreThe Inferno : Depiction And Representation Of Women2519 Words   |  11 PagesA subtopic worth further exploration within The Inferno is the depiction and representation of women. The Inferno mentions very few women throughout, and that makes it all the more salient to analyze the presence of these feminine cha racters for the fact that they are female carries more weight within the context of the poem than what they say alone. Dante lived in an era when women did not occupy influential roles in the public realm, and were actually discouraged from engaging in intellectual

Qantas Airways Strategic Management †Free Samples to Students

Question: Discuss aboiut the Qantas Airways Strategic Management. Answer: Introduction The Qantas Airways are the largest airline in Australia. The airline began in business by transporting mails and passengers. Currently, the company has its operations almost 140 destinations globally and largest employer in Australia with around 37,000 employees(Pearson Merkert, 2014). Human resource management operates in four areas: corporate, business segment, development and learning and shared services. The market segment, the HR staff, collaborates with other business segments to ensure delivery of the services that will assist in the competitive advantage. At corporate level, the HRM handles staffs remunerations, benefits, development of the management and industrial relations of the company with its competitors. Under, the development and learning, the HRM comes up with training programs to assist the worker in delivering work efficiently. Finally, the human resource has duties in the firm and under shared service(Hampson, Junor, Gregson, 2012). The paper will discuss the i ndustry attractiveness, resources, capabilities, core competencies and competitive advantages of the airline in great details, and come up with appropriate recommendation and conclusion. Currently, the aviation sector has been very competitive in many countries globally. Concerning the Qantas, although it is the largest aircraft in the Australia with higher domestic passengers, it is threaten by other emerging airlines worldwide(Hussain, Al Nasser, Hussain, 2015). Michael Porter model will help understand more about the Qantas airliner structure. Qantas operates a virgin blue airline with low cost. However, looking at the cost leadership strategy, it cannot help in the current competitive condition. It is because each aviation airline focuses on the cost reduction, and services delivery and having an excellent product that out does the competitor. And so, Qantas can concentrate on the differentiation strategy to strengthen the company to deal with other the competitor. Threat of the new entrant For instance, the Tiger Airways plans to set up a new base in Victoria's Avalon airport. For that reason, Qantas should know to create hurdles to a new competitor from global aviation like using price tactic with the jet star airline as subsidiary(Bereznoy, 2015). Also, association strategy crucial in building trouble Qantass competitors to create brand worth by diversity; create superiority feeling of the Qantas customers. To save time, individuals use a plane as a means of transport between countries or inaccessible places. Due to the alternatives such as automobiles, vessels and trains, the airline should try to come up with diverse options and encourage travelling at a lower cost to influence customers. The two primary provider of the aviation industry is aircraft manufacturer and fuel supplier. Qantas contracts the aircraft manufacturers such as Boeing, Bombardier and Airbus(Piercy, 2009). Hence, the influence of the airliner engineering firm can be great to transact with the Qantas airline. Another major supplier of the airline is the fuel which comes at higher cost. Both locally and all over the world, bargaining influence of the consumers can be extraordinary. Nationally, Qantas has a jet star which has several routes at comparatively low cost. Tiger Airways Australia is alternative airline offering a reasonably little price carriage (Piercy, 2009). Similarly, the bargaining control of the buyers in the global airline industry can be substantial. Consequently, numerous airlines are operating at a lower cost, offering several options and different promotion. So, Qantas should have a quality product at the lower price in various channels such as websites and travel agency. Core competencies The core competencies consist of the production process, staff, customer relationship and abilities of the acquaintance which assist in the company to reach its goals and objectives (Pearson Merkert, 2014). Similarly, strategic planning shows the possible method that the organization can come about in future. Also, the company can go along the new core competencies to create benefits and success. A strategic design like information and social planning is the ways to define the senior management. For the case of the Qantas airline, the organizations core competencies are exceptional airline with outstanding services (Park, 2007). Qantas airline utilizes their core competencies to make the corporation have competitive advantages. The Qantas airline employs their essential capabilities with Qantas and jet star airline; which are reliable trademark. Possessions are intangible or physical assets that business implements into corporate plans (Cui Li, 2015). Although the market advances powers and limits, a firms reaction to the resources capability and distribution development becomes a basis of competitive advantage. Thus, the capacity is how the company uses its resources to have a competitive advantage. For instance, for the Qantas airline, it has a cheapest and groundbreaking approach to the price cutting (Park, 2007). Additionally, it has simple processes and concentrates on the particular market segment. The Qantas airline has resources such as human resources, financials assets, intellectual capital and physical properties. Michael Porter's model comprises of generic strategies consisting of cost leadership, differentiate and focus strategy(Daft Albers, 2013). The airline manages two brands; Qantas and jet star airlines. Moreover, the company has other subsidiaries such has Qantas link, jet connect; jet star Airways and Express Freighters Australia. Differentiation strategy Through the differentiation approaches, the enterprise can lift the worth of the products to the commuters. In Qantas aviation firm, the safety and protection are primary consideration. Qantas group operates over 330,000 flights per year(Rieple Helm, 2008). Therefore, the organization is confident about outstanding management on safety platforms which differentiate it from other competitors. In addition, the Qantas international flights such as A380, A330 and B747 have provision for in-flight entertainment. Also, the airline provides its members with over 130 lounges globally with necessary facilities. Qantas groups operate various trips which totals to 173 terminals in 42 nation states. Thus, with grouping with other partner airways, it can heighten the significance of the product and create good customer relationship(Dwyer Edwards, 2009). Jet star centers on dropping cost of flights so as to capture market share with the main brand in a different market segment (Pearson Merkert, 2014). However, currently, there are airlines which still offer low-cost. For the airline to deal with leading competitor, it has to form partnership strategy so as offer lower prices than other fare airlines. Air Asia and jet star provide unsurpassed reach in the Asia-pacific region, with a reduced cost and more routes than their competitor and therefore this partnership alliance makes it maximize and enjoy economies of scale (Frederick Patil, 2009). Building on the same point, jet star recognizes the fast sale at a lower price to create new promotion and attract more customers quickly(Frederick Patil, 2009). SWOT analysis Qantas has a power which helps to compete with other airline industry. Qantas has an excellent marketing skill and perfect brand building exercises. It is through promotions and marketing which makes the company a noticeable airline service provider. It is well known that the enterprise is a long term partners of the cricket team and sponsor of formula one in Australia(Frederick Patil, 2009). Qantas has impressive and excellent safety records which are attractive to the passenger. Safe assurance of the passengers enables them to travel using the airline both domestically and internationally places. Additionally, Australia government provides the company with numerous tax benefits which assist the air in acquiring necessary materials at rational price. Moreover, Qantas enjoys the monopoly in the domestic market because it is the only airline in the Australia territory. The airline operating and labor cost is very high which makes it difficult to cope (Cui Li, 2015). So, the airline has some large subsidiaries which make it challenging to deal with complex and cost related hitches. On a regular basis, the airline experiences union disputes. The airline feels the pressure of working out on the employee's demands; the workers raise their demand from anywhere. Another issue is that there is a mixed fleet which makes the pilot train properly to be able to operate them. Training makes the airline to incur an additional operating cost. For Qantas to create a new airline in Asia, need to establish a fundamental relation to other countries government and also its people (Pearson Merkert, 2014). Therefore, the airline needs to capitalize on its strategies in the Asian market to make success like in the domestic country. Due to technology contributing immensely to the globalization, the airline should utilize on the E-commerce operation to extend service which will help to get more customers and offer passengers with more options (Frederick Patil, 2009). The Qantas has a significant market share and well-established ground due to less interest by other airlines in the domestic territory. The rise in labor cost has adverse effects on both short and long term difficulties. As results of pressure from union, force company to raise the wages to its staff at less working hours. It further led to lengthy discussions which affect the airline operation. All airlines have problems with rising fuel costs(Cui Li, 2015). Therefore, there will be effects on the activity, and this causes the airlines to change its focal plans so as tackle changes. Furthermore, for the government to save the small airline from the well-established airline from competition, the government set a strict rule and increases the government regulations(Fu, Homsombat, Oum, 2011). Recommendation Alan Joyce has to help the employees understand the importance of going global and also create a feeling of mutual understanding among the employee; so that they give him 100% desired results. Qantas management has to implement the human resource planning, try to reduce it weakness and try to work with its workers. Qantas has to gain a potential market share because Australia is turning into a business hub and international tourist destination center for the oceanic. The market in Asia has a significant and number of countries such as India, Japan, China, Korea and Singapore(Park, 2007). Since their competitor is less reliable and more expensive, the airlines can provide the special conditions which will attract more customers from their rivals. The airline should know how to tackle the issues of the fuels and labor cost to achieve its goals. The organization should become aware of the regulations protecting small rivals so that the government does not intimidate the airline. Finally , the Allan Joyce can give bonus and benefits to motivate the employees to perform at their optimal level. Conclusions Undoubtedly, Qantas has approved that is customer-driven organization due to its innovative and unique approach supported by the Australia government. There is a strong bond between the airline and customer because of the services offered at business and economy class. Qantas recognitions come as result of the various sponsoring sports which is lucrative and profitable. Additionally, the Qantas employs the strategy of the following limited amount of destination. Hence, fewer destinations make it provide better services in the world so far. Although it could be difficult for the Allan Joyce to maintain and form a continuous relationship with unions, it will help to create a new beginning in the airline history. References Bereznoy, A. (2015). Changing Competitive Landscape Through Business Model Innovation: the New Imperative for Corporate Market Strategy. Journal of the Knowledge Economy, 1-22. Cui, Q., Li, Y. (2015). Evaluating energy efficiency for airlines: An application of VFB-DEA. Journal of Air Transport Management, 44, 34-41. Daft, J., Albers, S. (2013). A conceptual framework for measuring airline business model convergence. Journal of Air Transport Management, 28., 47-54. Dwyer, L., Edwards, D. (2009). Tourism product and service innovation to avoid strategic drift. . International Journal of Tourism Research, 11(4), 321-335. Frederick, H., Patil, S. (2009). The dynamics of brand equity, co-branding and sponsorship in professional sports. International Journal of Sport Management and Marketing, 7(1-2), 44-57. Fu, X., Homsombat, W., Oum, T. (2011). Airportairline vertical relationships, their effects and regulatory policy implications. Journal of Air Transport Management, 17(6), 347-353. Hampson, I., Junor, A., Gregson, S. (2012). Missing in action: aircraft maintenance and the recent HRM in the airlines literature. The International Journal of Human Resource Management, 23(12), 2561-2575. Hussain, R., Al Nasser, A., Hussain, Y. (2015.). Service quality and customer satisfaction of a UAE-based airline: An empirical investigation. Journal of Air Transport Management, 42, 167-175. Park, J. (2007). Passenger perceptions of service quality: Korean and Australian case studies. Park, J. W. (2007). Passenger perceptions of service Journal of Air Transport Management, 13(4), 238-242. Pearson, J., Merkert, R. (2014). Airlines-within-airlines: A business model moving East. Journal of Air Transport Management, 38, 21-26. Piercy, N. (2009). Strategic relationships between boundary-spanning functions: Aligning customer relationship management with supplier relationship management. Industrial Marketing Management, 38(8), 857-864. Rieple, A., Helm, C. (2008). Outsourcing for competitive advantage: An examination of seven legacy airlines. Journal of Air Transport Management, 14(5), 280-285.

Open Racism Essay Example

Open Racism Paper When I think about is racism still alive today, a particular poem comes into mind its entitled:â€Å"Racism Is Around Me Everywhere†. | | â€Å"Of human ignorance I am almost in despair For racism is around me everywhere But like they say sheer ignorance is bliss Just like Judas betrayed Jesus with a kiss. Some people carry their honor in a flag And of their Nationality they brag They feel superior and they differentiate And against those who are different they discriminate. So many people still judged by their race For such there never ought to be a place A fair go those untruthful words I do recall There is no such a thing as a fair go for all. Though we live in a so called democracy Of racism we never will be free They judge you by where you come from and the color of your skin For many equality and respect seems impossible to win. Its been awhile since the days of Martin Luther King His name to it has a familiar ring If against racism he did not choose to strive Today the great man he would be alive. So many holding the reins of power not spiritually aware And racism is around me everywhere And racism only leads to division and war Just goes to show how ignorant some are. † (Frances Duggar) | | We will write a custom essay sample on Open Racism specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Open Racism specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Open Racism specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Racism is a belief held by some that there are characteristics and abilities can be attributed to people simply on the basis of their race and that some racial groups are superior to others. Racism and discrimination have been used as powerful weapons encouraging fear or hatred of others in times of conflict and war, and even during economic downturns. For people throughout the world, the election of Barak Obama to the U. S. presidency seemed to signal in a new era, that of the end of racism. Indeed, Obamas election was a momentous occasion and, one would have hoped, a milestone on the road to reconciliation. However, some recent, very ominous events cast a worrisome veil over the democratic process in the United States. These events points out how racism is still a problem in the United States. Racism occurs often times out of fear. Many people fear what is different to them and what they do not know. This in turn, makes it scary when you see people who look different than you do and sometimes, you treat those individuals differently because you do not know them. Racism occurs in different facets of society. Schools, the government and the workplace are sometimes the worst examples of racism. Racism in schools Millions of African American and Latino young people in the United States don’t get an education equal to that of most whites, partly because the urban schools they go to don’t have as much money as the schools in the white suburbs. This is because the country has decided that much of the money for schools should come from local property taxes. So in communities where the houses and businesses are less expensive, the schools don’t get enough money to provide a high quality education. This is unfair. This is institutional racism. If we financed schools differently every student, regardless of his or her race, could go to a high quality school that was the equal of the schools other students attend. The Government Hurricane Katrina: The government had known for years that a big hurricane was likely to cause dangerous flooding in New Orleans. The plans they made didn’t include any way to get poor people (predominately African Americans) out of the city to safety. When the storm and the flooding did come with Hurricane Katrina in 2005, much of the country saw on TV that thousands of people of color were stranded in the city without food, water, housing or safety. The government was incredibly slow to rescue people, to provide food and shelter, and to help them rebuild their houses. Many people believe that if those stranded had been mostly white people the rescue efforts would have been much quicker and effective. Racism in the Workplace Racism in the form of discrimination persists in society also. A case in point is that blacks have traditionally suffered from higher rates of unemployment than whites. In June 2009, black employment was at 15. 3 % compared to an 8. 8% unemployment rate for whites. Do blacks simply not take the initiative that whites do to find work? Studies indicate that, in actuality, discrimination likely contributes to the black-white unemployment gap. (Thompson) Critics will say how can racism still exists with the election of the United States first black president. Since President Obama took office he has been a rise of subtle racism against our president. It can be seen in the supporters of the new birthers movement, who stir up doubts about Obamas citizenship. During the 2008 presidential campaign, there was no impetus to question John McCain’s birthplace even though it was common knowledge that McCain was born in Panama; because he is white. The president’s birthplace should not have been an issue at all but yet to this day you still have a lot of Americans who still question his birthplace. Critics also say with electing our first minority president, and minorities reaching higher levels of education, obtaining more earnings and more distinguished careers, one might infer that prejudice is dead. I contend that it is alive and flourishing while lurking beneath the shadows of figures that naturally inflate with the growth of a burgeoning society. If racism does not exist then what accounts for â€Å" the wide range of disparities that still exist in society, most of which show black Americans with worse outcomes than whites in areas such as income, home ownership, health and employment, study researcher Samuel Sommers, a psychologist at Tufts University, said in a statement. When most Americans think of racism they think of the open racism back in the Civil Rights movement and during slavery times when crosses were burned in African-American yards. They think of the KKK when they think of racism which was upfront and in your face. The fact that the KKK and groups such as these that still exist prove the point that racism still occurs in the United States. While racism may not be as widespread as before, it exists, without a doubt. While we like to think that those unfortunate days of racism are behind us, it still exists. Today, racism is much less obvious and less prevalent. However, we are still reminded that racism is alive and well, and we must continue working to do away with it. Every day in the news there are stories dealing with the unfair treatment of minorities, women, and gays. America is the best country in the world because of the opportunity given to every individual and because of its constant struggle for equality of all. Any person, of any race, creed, or religion can succeed with hard work and determination. The problem is that the level of those individual’s success is sometimes determined, by the color of their skin. The race for social equality is persistent here, but there are still problems with the system. So, unfortunately racism does still exist today in the United States. References William-White, L. , White, J. (2011). Color Marks the Site/Sight of Social Difference: Dysconscious Racism in the Age of Obama. Qualitative Inquiry, 17(9), 837. Retrieved December 12, 2011, from Research Library. (Document ID: 2495960131). William March. (16 May). Researcher: Evidence shows racism in opposition to Obama. McClatchy Tribune Business News,. Retrieved December 12, 2011, from ProQuest Newsstand. (Document ID: 2348227321). Thompson Matthew (2011). Does Racism still exist today? Answers from Men. Retrived December 12, 2011 http://www. answersfrommen. com/2011/01/does-racism-still-exist-today/ Mosser, K. (2011). An introduction to logic. San Diego, CA: Bridgepoint Education, Inc. (https://content. ashford. edu) Pappas Stephanie. (2001) Study: Whites say they are racists’ victims. Retrieved December 12, 2011. http://www. cbsnews. com/stories/2011/05/24/scitech/main20065864. shtml http://poemhunter. com/poem/racism-is-around-me-everywhere/ http://www. politicususa. com/en/political-racism

Anthelmintics for Treatment of Parasites Animals Essays

Anthelmintics for Treatment of Parasites Animals Essays Anthelmintics for Treatment of Parasites Animals Essay Anthelmintics for Treatment of Parasites Animals Essay Vermifuges opposition is a cardinal issue within the veterinary field, to a great extent impacting carnal public assistance and the agricultural industries. ( Wolstenholme, Fairweather et Al. 2004 ) . Vermifuges are used as preventives and for the intervention of assorted parasites in animate beings, ruminants being the largest group, which the drugs mark. Of the many categories of vermifuges used there are three major categories used in the intervention and control of GI roundworms in sheep ; benzimidazoles / pro-benzimidazoles, imidazothiazoles/ tetrahydropyrimidines and avermectins/milbemycins. Each of these drugs categories have different mechanisms of action but all consequence merely the parasite holding minimum consequence on the host. This issue is of import when the weights of animate beings is unknown and an over dosage may be given. ( Urquhart 1996 ) . The category benzimidazoles/ pro-benzimidazoles consist of fenbendazole, oxfendazole, albendazole and other similar moving drugs. They target a protein ( beta tubulin ) distributed within microtubules, and both plasma and mitochondrial membranes. These aid the formation of farther microtubules, which in bend consequences in a decrease in glucose consumption and protein secernment, taking to decease by famishment. ( Taylor, Coop et Al. 2007 ) . This group chiefly effects nematodes including their eggs and has a low, sometimes negligible toxicity to the host. ( Urquhart 1996 ; Taylor, Coop et Al. 2007 ) . Resistance against vermifuges occurs the most extensively within this category. Imidazothiazoles/ tetrahydropyrimidines include four chief drugs levamisole, pyrantel, morantel and tetramisole. ( Urquhart 1996 ) . Levamisole is one of the chief drugs used against roundworms in sheep, as it has a broad spectrum of activity against different species, nevertheless it is non ovicidal. ( Taylor, Coop et Al. 2007 ) . In both the host and nematode the drug acts as a depolarizing neuromuscular blocking agent. ( Urquhart 1996 ) . This means the parasite is paralysed and expelled fleetly. As the host is targeted besides, side consequence can include hyperactivity for a short period after dosing and increased cellular activity. Unlike benzimidazoles, imidazothiazoles can hold a toxicity effects from nervus ganglia stimulation. Death can happen in extreme over doses. Both pyrantel and morantel act as selective agonists, copying the action of acetylcholine. This consequences in a speedy palsy and ejection of the worms via gut vermiculation. ( Taylor, Coop et Al. 2007 ) . Imid azothiazoles tend to hold a short action and can be used against other helminth groups. The last group of vermifuges used for nematode control in sheep, are the avermectins/milbemycins, besides known as macrocyclic lactones. Avermectins include ivermectin, doramectin, eprinomectin and selamectin, where as milbemycin and moxidectin make up the milbemycins group. The two bomber groups differ in their construction make up but are both effectual against a wide spectrum of activity against roundworms and other arthropods. Even at low doses the drugs are good absorbed systemically remaining within the host for a figure of hebdomads after disposal. ( Taylor, Coop et Al. 2007 ; Urquhart 1996 ) . However due to this drawn-out life, it is indispensable that the animate being is withdrawn from nutrient production subsequent to any interventions, although eprinomectin can non be given to breastfeeding herd. The mechanism of this group is non wholly known but it is thought that they act on glutamate gated chloride conductance channels at the neuromuscular junction. ( Taylor, Coop et Al. 2007 ) . The overall consequence is flaccid palsy of the bodily muscualture, which in bend inhibits feeding actvity. Increased use of any of the anthelminthic categories can take to a physique up of opposition. Resistance can originate within a nematode population, when the frequence of persons which can defy the action of the drug given, additions. The survival trait is so inherited by the roundworms progeny developing the opposition farther. Numerous signifiers of opposition depend on the manner of action of the drug. For illustration, side and cross-resistance where the choice for a drug occurs from holding the same or different manner of action of another. Multiple oppositions can come about when roundworms are opposition to two or more different vermifuges groups. ( Prichard, Hall et al. 1980 ) . Resistance normally is a consequence of an addition in the frequence of the anthelminthic, nevertheless, it can besides be selected when the drug is administered at a low frequence over a longer period of clip. ( Jabbar, Iqbal et Al. 2006 ) For illustration, it was found on the islands of Greece that sheep dosed merely two or three times yearly, still incurred opposition over a figure of old ages. ( Coles, Papadopoulos et Al. 1995 ) The rate at which the opposition builds up depends on several facets. The most important include the frequence of worms in refugia, the figure of of course immune worms within the untreated host population and the survival ability of the opposition worms when faced with a drug onslaught. ( Coles 2005 ) . Geneticss besides play a cardinal function in finding the rate of opposition. As with any trait if the cistron is dominant it will be passed on to progeny at a faster rate than if the cistron was recessionary. This has been seen within the opposition cistrons of Haemonchus contortus, against both levamisole and ivermectin, where they demonstrate either a recessive or a dominant nature, severally. ( Sangster, Redwin et Al. 1998 ; Le Jambre, Gill et al. 2000 ) When dosing animate beings, the drug should choose for the dominantly familial resistant worms intending the recessively familial resistant worms will last. This will cut down the rate at which opposition occurs. ( Prichard 1990 ) Many of the GI roundworms have built up either individual or multiple signifiers of opposition against the drugs used for intervention and control. The mechanism against each of the categories differs, due to the manner of action of the drugs themselves. As Haemonchus contortus and Trichostrongylus colubrifoemis are used to show the opposition of mechanism benzimidazole. The immune cistrons occur from two separate beta tubulin loci isotype-1 where allelomorphs are lost. ( Roos, Kwa et Al. 1995 ) There are a figure of trials that can be used to show opposition, runing from fecal egg count decrease trial ( FECRT ) to PCR. Trials can be specific to a category of vermifuges or used with any of the groups. ( Coles, Jackson et Al. 2006 ) . Trials fall three chief classs ; public presentation based, in vivo and in vitro. ( Jabbar, Iqbal et Al. 2006 ; Kenyon, Greer et Al. 2009 ) A combination of epidemiological and public presentation ratings can be utilised to observe anthelminthic opposition. Livestock weights can be used as indexs for worm loads, as weight addition diminutions if there is a heavy infection. This is seen with sheep infected with gastrointsetinal roundworms, particulary with lambs where weight falls prior to any clinical symptons. ( Coop, Sykes et Al. 1977 ) There are two methods used which rely on weight addition or loss. ( Kenyon, Greer et Al. 2009 ) . Although in New Zealand, Teladorsagia spp was found to hold developed less opposition to intervention, when the heaviest 15 % of lambs were elminated from dosing during the graze season. ( Leathwick, Miller et al. 2006 ) This implies that the heavier lambs are of course infected with the parasite from the grazing land, and accordingly weight addition lessenings. As parasites are exposed less to the anthelminthic, opposition patterned advance slows. To quanitify this techneque, energy deposition and consumption are calucated.Environmental factors are taken into history when ciphering the energy. ( Greer, Kenyon et Al. 2009 ) As environmental factors are taken into history, intervention efficaciousness values can be applied throughout the twelvemonth, within and out of the graze season.Individuals are so predicted their weight addition and intervention is given whether or non weight addition is expected. ( Kenyon, Greer et Al. 2009 ) . In vivo trial are any which require the carnal itself and include fecal egg decrease trials, critical vermifuges trials and the controlled vermifuges efficaciousness trial. ( Jabbar, Iqbal et Al. 2006 ) FECRT can be used on any of course infected carnal casting fecal roundworm eggs, against any anthelminthic. Faecal egg counts are taken prior to intervention and once more one time intervention is administered. A comparing can so be made to find whether the egg counts are affected by the anthelminthic. ( Coles, Bauer et Al. 1992 ) . The clip between disposal and mensurating the fecal egg count can change, depending on the drug used. For illustration if levismisole or morantel are given the FECRT should be conducted seven yearss after intervention as the drugs are fast moving. However if a benzimidazole is administered, egg counts should be performed eight to ten yearss after the intervention. This group of drugs along with the avermectins/ milbemycins, has a impermanent sterilising action on female worms intending the females can non bring forth eggs. ( Coles 2003 ) When an avermectin is administered the sheep should be left for about two and half hebdomads. If all three groups are t ested for at one time attention demands to be taken, as if the fecal counts are left until three hebdomads after intervention so larvae caught station disposal may develop into mature grownups. ( Coles 2005 ) To number the figure of existent eggs found in sheep fecal matters, the McMaster method affecting centrifuging and repairing slides, can be used, nevertheless a more convenient on-farm method has been developed. The FECPAK uses a system of thining the fecal mixture and adding a salt solution, eventually being sieved to be so fixed on the slide. The technique tests nematode eggs to a sensitiveness of 30 eggs per gm, although, it is non every bit sensitive as the research lab method. ( Coles 2003 ) . The cardinal advantage to this technique is that it non merely has an on-farm FECRT, but it works with all of the anthelminthic groups. ( Coles 2005 ) It can be besides used as an index of what type of anthelminthic flock government should be practiced ( Leathwick, Waghorn et Al. 2006 ) .However, the trial merely reviews the figure of eggs found in fecal matters samples. The vermifuges efficaciousness will non be an accurate representation of the true figure of worms, including larvae, populating in the host. ( Jabbar, Iqbal et Al. 2006 ) . In most species of roundworms this is the instance, although it has been found that Haemonchus contortus bears a strong correlativity between its fecal egg counts and true worm loads. ( Sangster, Whitlock et Al. 1979 ; Chalmers 1985 ) . In countries where multiple species of worm infections occur, the high worm and egg production of Haemonchus contortus can mask Numberss of other worms such as Teladorsagia circumcincta, which has a lower egg produ ction rate but still may hold a degree of opposition. ( Kenyon, Greer et Al. 2009 ) . Resistance ideally needs to be detected at the early phases to avoid it distributing across the flock population. ( Sangster and Gill 1999 ) Although FECPAK is available on the market, most FECRT require research lab analysis, so the consequence takes clip to be evaluated. ( Kenyon, Greer et Al. 2009 ) . Within the period in which the husbandman may be expecting the analysis, the flock may endure if the worm load is big. The husbandman will non may non merely lose stock but the finicky costs of intervention may increase. Resistance is detected if either of the followers are established ; the 95 % confident interval degree peers or is less than 90 % , and if the egg count decrease is less than 95 % . ( Coles, Bauer et Al. 1992 ) . The critical anthelminthic trial has a strong advantage of that, although few animate beings are used, they act as their ain control. The process compares the figure of worms present station intervention to the figure in the animate beings post slaughter review. Faecal samples are taken for a lower limit of four yearss after the drug is administered. Both the residuary worm Numberss and the efficaciousness per centum are so determined. ( Gordon 1950 ) . The chief disadvantage of this trial nevertheless, is that it the worm Numberss can merely of all time be estimated as roundworms found in the GI piece of land of sheep undergo a grade of digestion. ( Reinecke 1962 ) . The trial is both clip and labor consuming, intending the consequences are non instant for finding the needed intervention. ( Johansen 1989 ) . The last in vivo trial, which can find anthelminthic opposition, is the controlled anthelminthic efficaciousness trial. Animals here are unnaturally infected with roundworms that are suspected of being opposition to specific drugs. The anthelminthic activity of all phases of the parasite development can be evaluated by butchering the hosts at different intervals post-treatment. ( Reinecke 1962 ) . Resistance is found when the figure of worms, which survived the intervention, is greater than a 1000 or if the decrease figure is less than 90 % . Normally ranges of anthelminthic doses are used, intending dose-response parametric quantities can be determined. Although assorted parasites can used with this technique, in bred lines of animate beings are normally used to extinguish any single prejudice. A major disadvantage with this trial is that it requires skilled personal to execute station mortem scrutiny, connoting that it can non be routinely used for sensing of anthelminthic opposition. ( Johansen 1989 ) . In vitro techniques are one those conducted in the research lab. These techneques exploit physiological traits of the roundworm such as growing, motion and development. ( Conder and Campbell 1995 ) . Compared to in vivo techneques, in vitro are cheaper, utilizing fewer animate beings and chemicals to prove are big sample. Non-bias reproduction can be performed, with hastiness, to measure the efficaciousness and opposition of drugs. However in general, labaoraory surveies are do non resemnle field conditions, intending the drug may interact otherwise with the parasite and host. ( Sangster and Gill 1999 ) . The egg hatch trial is the most common in vitro trial, specifically observing the opposition of benzimidazoles. ( Coles, Bauer et Al. 1992 ) . There are legion methods which can be used, all trusting on the vermifuge s ovicidal trait and for the eggs to hold a grade of opposition. The development of the eggs is depressed within the early phases of development due to the larvae going non-compliment to the anthelminthic ovicidal action. ( Lejambre 1976 ) . The technique was foremost illustrated by Le Jambre ( 1976 ) . Fresh sheep fecal matters incorporating roundworm eggs are collected. This is one of the disadvantages, as when applied on the field, fecal samples may non be excreted within three hours, which is what defines a sample as fresh. If this is non executable samples may be stored anaerobically. ( Coles, Bauer et Al. 1992 ) . A cardinal advantage of this method if that merely one fecal sample is needed. ( Jabbar, Iqbal et Al. 2006 ) . Once the facecal samples are collected, egg are deposited into welled home bases and a graduation of anthelminthic concentrations are added. Using assorted concentrations prevents more than 50 % of the eggs hatching. Eggs are than incubated and so put through a procedure of I lavation. The dosage needed to kill 50 % of the eggs is so calculated. ( Coles, Bauer et Al. 1992 ) . The discrimintating dosage is can besides be calculated. This prevents 99 % of the eggs hatching and hence any eggs that do hatch are immune to the drug. 0.1mg per milliliter of thiabendazole has been found to be the discriminating dosage for Haemonchus contorus, T. Circumcincta and Trichostrongylus. ( Coles, Jackson et Al. 2006 ) . Although merely one sample of fecal matters is needed, undeveloped eggs are needed for the nosologies. ( Coles and Simpkin 1977 ) Newer benzimidazoles, such as fenbendazole, have a lower solubility, which reduces their ovicidal action. The egg hatch trial, hence, can non be used to research opposition of some specific drugs. This can present as a job as the new found benzimidazoles are normally used in pattern. ( Lacey and Prichard 1986 ) . Although this is a important disadvantage of the method, thiabendazole ( Jabbar, Iqbal et Al. 2006 ) , which can be used in the trial, has demonstrated to hold side opposition wth other benzimidazoles, so any opposition found in thiabendazole may be applied to other drugs of this category. ( Martin, Anderson et Al. 1985 ) Another concern of the egg hatch trial occurs during the numeration of the eggs. Larvae, embryonated eggs and simple larvae are counted to cipher about the effects of the drug. Merely a little proportion of the embryonated eggs of the vulnerable roundworms, hatched. The proportion that hatched decreased when the drug concentration increased. However, when looking at the immune strains, the bulk of the eggs hatched. When the per centum of the eggs that hatched is calculated, the opposition ratio will be lower, when compared to when the larvae or embryonated eggs are counted. The ratio of opposition is the egg count opposition to the egg count susceptibleness. ( Johansen 1989 ) Although the trial is fast, taking merely one to three yearss, European research lab egg hatch testings, frequently result in assorted decisions being drawn from the same population of Haemonchus contortus. The analysis established that the H2O samples, cleaniness and trying method used, differed. ( Coles, Jackson et Al. 2006 ) . Egg hatch trials are besides used utilizing levamisole, where the figure of hatches are counted to use any differences between both immune and vulnerable strains. Their rate of recovery from paralysed unhatched larvae to hatching is measured when exposed to the drug. ( Dobson, Donald et al. 1986 ) The check is faster than for benzimidazoles ; nevertheless, the levamisole trial is more labour demanding. ( Johansen 1989 ) . Both FECRT and the egg hatch trial merely demonstrate anthelminthic opposition when any bar methods are excessively late to implement. ( Jabbar, Iqbal et Al. 2006 ) . The larval palsy trial is used against levamisole and morantel opposition. ( Martin and Lejambre 1979 ) The technique involves L3 phase larvae being incubated within assorted dilutions of the vermifuges. Assorted reappraisals have been reported about this method, proposing both failures and success. The chief issue of concern is the dependability of th consequences and their relationship to the age of the larvae. ( Geerts, Brandt et Al. 1989 ; Jabbar, Iqbal et Al. 2006 ) This trial is known to back up in vivo method, as it is more sensitive than either FECRT and EHT, observing opposition in less than 10 % of worms. ( Dobson, Lejambre et Al. 1996 ) Another in vitro trial used to show anthelminthic opposition is the larval development check. This trial can measure a wider spectrum of categories integrating macrocyclic lactones, nevertheless it does necessitate more clip and labor so antecedently described trials. The trial involves exposure of the L1 larvae to assorted diltutions of drugs within agar home bases. The larvae are left to develop until the L3 phase is reached, and so later measured. ( Jabbar, Iqbal et Al. 2006 ) . When proving an infection with multiple roundworm species, the different species can be detected easy with this technique compared to other methods discussed. ( Johansen 1989 ) A more specific trial used in the sensing of anthelminthic reistance within Trichostrogylid is the grownup development trial. Unfortunately there are restrictions within the methodological analysis of the technique and so advancement is resitricted. ( Jabbar, Iqbal et Al. 2006 ) The larval motility trial is used to place opposition within the two major categories of vermifuges, but fails to effectual with the sensing of levamisole opposition. ( Sangster, Riley et Al. 1988 ) . Again as the trial used complexed equipment, it can merely be applied to the labaortory and non used out in pattern. ( Conder and Campbell 1995 ) . The technique involves dosing the roundworms with dilutions of the anthelminthic drug, followed by the percebtage of the paralysed L3 phase larvae being calculated. Normally both a known susceptible and immune strain of the parsites are used for a comparing to be deduced. ( Johansen 1989 ) A cardinal advantage of this technique is the usage of L3 larave. These be acquired easy in big Numberss from faceal samples and abled to be stored for longer periods of clip. Unforuntaly the trial has some major drawbacks. The check is extremely dependent on clip, whereby any miscounted larvae can non be kept for future computations one time out of storage. ( Johansen 1989 ) . As the benzimidazole s mechanism is to adhere to beta tubulins, a technique has been developed to prove resistant utilizing this alone belongings of the drug. From either the grownup parasites, morbific larvae or egg, a rough infusion of tubulin is produced. Titrated benzimidazole ( with label ) is added, until an equilibrium is reached. ( Lacey and Snowdon 1988 ) . Charcocal is used to pull out the drug in its free signifier, go forthing the bound drug to the tubulin infusion withn the solotuion. An appraisal is so made with a complex liquid spectrometer. As predicted the tubulin from immune strains binds to fewer drug compounds than the more vulnerable strains. ( Johansen 1989 ) . An advantage of the tubulin bindning check, is that it relies on the biochemical traits of the drugs s mechanism. Compared to other in vitro techniques it used in a more dependable comparing with field based trials, every bit good as holding a speedy turnaround from the gathered sample to the consequence. However complexed research lab machines are still used by skilled workers, together with radioactive isotopes, necessitating specialised safety installations. ( Johansen 1989 ) . PCR, otherwise known as polymerase concatenation reaction trials, have been developed for benzimidazoles chiefly but research is trying to understand the molecular mechanism for levamisole and macrocylic lactones. To come on into any of the trial discusses above, a PCR will hold been conducted against the particlaur drug in usage. ( Coles, Jackson et Al. 2006 ) . First, for a PCR trial to be conducted, DNA is extracted from the larvae. A specific concentration is needed per micro bath, as any varioation between them may take to incorrect DNA sequences being developed. For the peculiar acknowledgment of the benzimidazole, two consecutive PCRs are ran on the isotope beta tubulin, magnifying the Deoxyribonucleic acid. The species of parasite is so established by utilizing the this fragment analysis. For illustration Haemonchus contortu or T. Circumcincat may be found. This is a cardinal advantage of PCR, as with other trial the visual aspect of the species is used to set up its individuality PCR, hence used an accurate method of placing the species by its genome. ( Coles, Jackson et Al. 2006 ) . Following this designation, in entire four sets of primers are used, two being allele non-specific, the others being allele particular. Fragments are so produced, separating between either resistant or vulnerable homozygote strains. ( Coles, Jackson et A l. 2006 ) . When four primers of benzimidazole opposition were used, positive consequences were obtained with the parasite T.circumcinta. Similar consequences were found utilizing merely three immune primers with H. Contortus and T.colubriformis ( Silvestre and Humbert 2000 ) . When used in the field, the gathered sample will frequently be a assorted population of roundworms. The frequence of which the allelomorphs will happen will straight depend on the fraction of the roundworm within the entire population. ( Coles, Jackson et Al. 2006 ) . The trial proves that both the homozygote and heterozygote allelomorphs are vulnerable to the drug, connoting that opposition arises from homozygous of the tyrosine. As benzimidazole opposition in Trichostrongylus is to a great extent researched utilizing this trial, it has been established that the resisatance occurred due to a mutant of phenylalanine to tyrosine of the isotope 1 cistron encoding for the beta tubulin. It was utilizing this footing that that the usage of PCR to observe drug opposition in gastro intestinal of sheep Cam about. Although in theory, this appears to be the most accurate, the mutants of parasite doing the drug resistant must be known. The greater the possibility of nematode mutating to go more residtant, such as within sheep, the more inaccurate PCR will go. Unfortunately, nevertheless, in some instances this is the lone opposition detection technique for some benzimidazoles. Compared to other trial available on the market, PCR is an expenisive trial to use to observe on-farm resisatnce. ( Coles, Jackson et Al. 2006 ) . Kwa M.S. , Veenstra, J.G. and Roos, M.H. , 1994. Benzimidazole opposition in Haemonchus contortus is correlated with a conserved mutant at amino acid 200 in B A ; z.eth ; -tubulin isotype 1. Mol. Biochem. Parasitol. 63, pp. 299-303 The most common molecular mechanism that confers BZ opposition in trichostrongyles in little ruminants involves a phenylalanine to tyrosine mutant at residue 200 of the isotype 1 b-tubulin cistron ( Kwa et al. , 1994, 1995 ; Elard et al. , 1996, 1999 ) . However, in add-on a similar mutant at codon 167 may be involved in BZ opposition in roundworms ( Prichard, 2001 ; Pape et al. , 2003 ) and there could be other specific mechanisms. Although ailing efficient, non-specific mechanisms such as drug conveyance may besides confabulate opposition ( Xu et al. , 1998 ; Kerboeuf et al. , 1999 ) and could even confabulate advantage to a worm when a fresh drug is introduced. The cardinal issue is that merely when a diagnosing based on utilizing pooled larval DNA samples can be obtained will it be possible to convey molecular immune proving to routine usage. Testing of representative Numberss of individual phases is prohibitively expensive. Besides the available molecular trials chiefly address opposition in species where the job is widespread and in some instances may be excessively common to warrant testing. Conclusion-8.3. coles-The sensing of anthelminthic opposition in roundworms of veterinary importance Larval development trial There are presently two larval development trials of involvement, the liquid based trial described by Hubert and Kerbouf ( 1992 ) and the agar based trial of Gill et al. ( 1995 ) . Is one easier to utilize than the other? Whilst they appear to work for BZs and LEV in ovine and equid roundworms they do non look to work with MLs and have non been produced for usage with bovine roundworms. As for the EHT big sums of informations demands to be collected before a SOP and its readings can be agreed. In peculiar the relationship needs to be determined between these standardised trials and the FECRT. Although the LDT will work for BZ opposition, it appears non to be as Chalmers, K. ( 1985 ) . Detection of Benzimidazole Resistant Nematodirus-Spathiger. New Zealand Veterinary Journal 33 ( 4 ) : 53-53. Kales, G. ( 2003 ) . Strategies to understate anthelminthic opposition in big carnal practice. In Practice 25 ( 8 ) : 494-499. Kales, G. C. ( 2005 ) . Anthelmintic resistance-looking to the hereafter: a UK perspective. Research in Veterinary Science 78 ( 2 ) : 99-108. Kales, G. C. , C. Bauer, et al. ( 1992 ) . World-Association-for-the-Advancement-of-Veterinary-Parasitology ( Waavp ) Methods for the Detection of Anthelmintic Resistance in Nematodes of Veterinary Importance. Veterinary Parasitology 44 ( 1-2 ) : 35-44. Kales, G. C. , F. Jackson, et al. ( 2006 ) . The sensing of anthelminthic opposition in roundworms of veterinary importance. Veterinary Parasitology 136 ( 3-4 ) : 167-185. Kales, G. C. , E. Papadopoulos, et al. ( 1995 ) . Tubulin, Resistance and Worms. Parasitology Today 11 ( 5 ) : 183-184. Kales, G. C. and K. G. Simpkin ( 1977 ) . Resistance of Nematode Eggs to Ovicidal Activity of Benzimidazoles. Research in Veterinary Science 22 ( 3 ) : 386-387. Conder, G. A. and W. C. Campbell ( 1995 ) . Chemotherapy of Nematode Infections of Veterinary Importance, with Particular Reference to Drug-Resistance. Advances in Parasitology, Vol 35 35: 1-84. Coop, R. L. , A. R. Sykes, et al. ( 1977 ) . The consequence of a day-to-day consumption of Ostertagia circumcincta larvae on organic structure weight, nutrient consumption and concentration of serum components in sheep. Res Vet Sci 23 ( 1 ) : 76-83. Dobson, R. J. , A. D. Donald, et al. ( 1986 ) . An Egg-Hatch Assay for Resistance to Levamisole in Trichostrongyloid Nematode Parasites. Veterinary Parasitology 19 ( 1-2 ) : 77-84. Dobson, R. J. , L. Lejambre, et al. ( 1996 ) . Management of anthelminthic opposition: Inheritance of opposition and choice with relentless drugs. International Journal for Parasitology 26 ( 8-9 ) : 993-1000. Geerts, S. , J. Brandt, et al. ( 1989 ) . Reliability and Reproducibility of the Larval Paralysis Test as an Invitro Method for the Detection of Anthelmintic Resistance of Nematodes against Levamisole and Morantel Tartrate. Veterinary Parasitology 30 ( 3 ) : 223-232. Gordon, H. M. ( 1950 ) . Some facets of parasitic gastro-enteritis of sheep. Aust Vet J 26 ( 4 ) : 65-72. Greer, A. W. , F. Kenyon, et al. ( 2009 ) . Development and field rating of a determination support theoretical account for anthelminthic interventions as portion of a targeted selective intervention ( TST ) government in lambs. Veterinary parasitology 164 ( 1 ) : 12-20. Jabbar, A. , Z. Iqbal, et al. ( 2006 ) . Anthelmintic opposition: the province of drama revisited. Life Sci 79 ( 26 ) : 2413-31. Johansen, M. V. ( 1989 ) . An rating of techniques used for the sensing of anthelminthic opposition in nematode parasites of domestic livestock. Vet Res Commun 13 ( 6 ) : 455-66. Kenyon, F. , A. W. Greer, et al. ( 2009 ) . The function of targeted selective interventions in the development of refugia-based attacks to the control of GI roundworms of little ruminants. Veterinary Parasitology 164 ( 1 ) : 3-11. Kenyon, F. , A. W. Greer, et al. ( 2009 ) . The function of targeted selective interventions in the development of refugia-based attacks to the control of GI roundworms of little ruminants. 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Comparison of numbers of organisms In Coniferous And Deciduous Woodlands Essay Example

Comparison of numbers of organisms In Coniferous And Deciduous Woodlands Essay Example Comparison of numbers of organisms In Coniferous And Deciduous Woodlands Paper Comparison of numbers of organisms In Coniferous And Deciduous Woodlands Paper An experiment was done to find out whether there was a difference in the number of organisms in the coniferous and deciduous woodlands. A quadrat of 10m by 10m was used and co-ordinates 5,1 5,2 5,3 5,4 5,5 5,6 5,7 5,8 5,9 5,10 were used because these were exactly in the middle of the quadrat area. Ten samples of leaf litter and ten samples of humus was obtained from each woodland. In the laboratory tullgren funnels were set up, the samples were tested and the organisms were collected. A results table was made to record the numbers of organisms in. The results were displayed in graphs and tables. The graphs show the average number of each organism and the actual number of each organism in each of the woodlands. In the third graph five significant organisms have been picked out. This is because they have significant values and reasons for these values. The tullgren funnel was set up using a certain amount of the leaf litter that acted as a sieve that the organisms could fall through from the humus that was placed on top of the leaf litter. 20g of humus and 10g of leaf litter was used in the tullgren funnel because only a small amount was needed. A 100w bulb was used in both experiments (for each woodland). The organisms were driven, by the drying effect of the bulb, down the tullgren funnel and eventually they fell into the 30cm3 of ethanol. The organisms died but their bodies were preserved so that at the end of five days the different organisms in the ethanol and the larger organisms in the dried up leaf litter could be identified and recorded using a microscope and a dichotomous key. This method was used because it was the most reliable, and ensured that all organisms present were removed from the sample in the tullgren funnel. Some very small organisms that were not affected by the drying effect of the bulb were not counted. During the experiment predation between organisms were occurring, this was not accounted for. The average test and the t-test were used, because two averages were being compared and there were less than 25 unmatched organisms in each sample. The value of t = 5.524 was greater than the value given for 22 points of freedom so that the Ho (null hypothesis) was rejected and the alternative hypothesis was accepted. Therefore the assumption, that the number of organisms are greater in the deciduous woodland, can be made. So the number of organisms did differ in the deciduous and coniferous woodland. The decomposition rate in the deciduous woodland is faster because organisms such as the earthworm can survive in this environment, because this environment is more alkaline than the coniferous woodland, which is more acidic. If conditions are less acidic then organisms such as the earthworm can survive and continue the fast decomposition, keeping the surrounding environment more alkaline. This is a negative feedback effect. So the number of species was greater deciduous woodland, with the exception of Springtails and small spiders. This is because these organisms have adapted to the acidic conditions of the coniferous woodland. Hypotheses Null Hypothesis (Ho) there was no difference in the number of organisms in the two soils. Alternative Hypothesis (H1) there was a difference in the number of organisms in the two soils. The Aim The aim of this investigation is to compare the difference in numbers of invertebrates in the coniferous and deciduous woodlands when samples are taken from each. The samples taken will be tested, recorded and evaluations will be made. Prediction The data collected will show that a coniferous woodland will contain fewer of the organisms that have been selected for study than in the deciduous woodland, and also that the depth of leaf litter will be considerably more in the coniferous woodland than in the deciduous woodland. Evidence In the deciduous woodland where the experiment was done, many different species of trees were growing. These trees have large, thin green leaves, to absorb the maximum amount of sunlight available. When these leaves fall off the trees to the ground, detritivores such as the worm, start the chain of decomposition. Without the detritivores the saprophytes (bacteria) cannot continue the process, after the detritivores, of breaking down the complicated organic matter. These leaves have a large surface area for detritivores to start the process of decomposition. Decomposition occurs relatively quickly therefore the layer of leaf litter will be thinner. However, in the coniferous woodland where the experiment took place there was only one species of tree and that was the pine. The pine needles are long and thin which are thought to increase the surface area for the absorption of sunlight. This surface area is also where, when the pine needles fall to the ground, the detritivores start the process of decomposition. Because of the conditions in the coniferous woodland the detritivores take longer to decompose the leaf litter. Therefore if the rate of decomposition is slow, and the rate of the pine needles falling are fast, then there will be more leaf litter on the ground of the coniferous woodland than on the floor of the deciduous woodland. The exotic conifer grows at a faster rate than the native broardleaves. Because the conifer is exotic, there are few insects and birds associated with it and so the exotic conifer is useless for use by native organisms. Because conifers are planted as a monoculture they are easy to manage (i.e. planting, weeding, fertilising, etc). But each tree needs exactly the same amount of nutrients and water because they are of the same species. This causes a deficiency of nutrients in the soil and so fertilisers have to be used. This could eventually lead to pest epidemics and so pesticides may also be needed. When a monoculture is planted, all the trees are of the same age and so are easily managed because there is little variation in height. The conifer woodlands and forests are planted in straight lines and are therefore easier to manage. However, this arrangement looks odd and unnatural because trees in a deciduous woodland are not planted in this way. If the conifers are planted densely then this ensures reduced side branch growth and increased height (therefore increasing the value of the timber). If all the trees are removed at the same time there will be a drastic change of the landscape which may result in a large amount of soil erosion. Variables * Light intensity in the coniferous woodland = 3.5 * Light intensity in the deciduous woodland = 3.5 * Temperature in the coniferous woodland = 28oC * Temperature in the deciduous woodland = 27oC Syllabus Areas Climate (i.e. local and micro climates, vegetation, landuse, topography). The Lithosphere (i.e. soils, nutrients, acidity). Ecological Relationships (i.e. ecosystems). Soil (i.e. conservation, cultivation techniques). Mathematical Skills (i.e. plotting graphs, understanding graphs, etc).

Harley-Davidson in 2004..2011 Essay Example | Topics and Well Written Essays - 1250 words

Harley-Davidson in 2004..2011 - Essay Example The global market consumers consider all the factors while purchasing the motorbikes because the motorbikes in most of the countries are used by means of transport or the consumers who does not afford the cost of maintaining car: The motorbike industry of US is different from the international market because the US consumers do not use the motorbikes by means of transport. So US consumers do not consider all the above factors except superior quality. Every country has its own economic conditions that are different from the other country. In motorbike industry of under developing countries the consumers consider these factors: cheap in cost, average in quality, fuel efficient and spare parts available at cheap prices. And in the developed countries the focus of the consumers on superior quality, innovative features and designs etc. the economic conditions of a country creates a big difference in the consumer preferences. 2.1-The motorbike industry is growing very fast for the last two decades and now the total number of motorbikes in the world is around 200 million. It’s a very huge market with a huge growth every year. Many bug multinational entering in this fast growing market because in the under developing countries motorbikes is used as a means of transport and in developed countries it is used with a broad perception. Harley Davidson associates its brand image with life style of customers. Its market is increasing because today’s consumer associate it self with the product’s characteristics to build its personal image as a products image. This trend makes the market of Harley Davidson more effective and appealing. Harley Davidson is most selling motorbike brand in US market and containing a highest market share in the US motorbike industry. The sales and the market share of Harley Davidson in the US motorbike industry

Write an analysis of 2000 words of one of the following Hong Kong Essay

Write an analysis of 2000 words of one of the following Hong Kong films - Essay Example Moreover the martial art of Kung Fu widely acclaimed in China is found to act as a common stunt piece for many Chinese, Japanese and Hollywood films. Further observation made suggests that the Chinese martial art form, Kung Fu has earned a figure statement. With Kung Fu mostly masculine bodies with high power muscles earning a spectacular vision is mostly tied to. Thus, the martial art of Kung Fu has been associated to a body genre accompanied by heavy sound effects like shrieks and thuds. To this extent, it is found that the Chinese martial arts films are the products of a culture mix. (Hunt, 2-3). The martial arts used in the Chinese film industry in the late 1960s emanated from the tactics used by the Samurai form of Japanese Martial Art. Research made suggests that in the earlier periods of Hong Kong film industry the Chinese form of martial art drew a fictional significance to that of the western action films. Moreover it was found that the Kung Fu form of Chinese martial art was blended with other cinematic instruments such as comedy, stunt and action filled antics. Even it is observed that film stars who were previously well known for their martial art skills now using less of martial art skills and focusing on showing stunts and antics. The level of stunts used in the Hong Kong action films owes their contribution to the effect of Chinese Opera on the fighting stars. However, it is recognized that still the fighting choreography has a close resemblance to the traditional martial arts form. The Kung Fu form of martial art finds its connection to the Southern part of the Chinese republic. Northern China was more concerned with the advent of sword fighting techniques used in action films. However, the use of Kung Fu in the Hong Kong action films has helped the cinemas earn a global repute in a short span of time. The Kung Fu films

Evaluation Essay Example | Topics and Well Written Essays - 500 words - 3

Evaluation - Essay Example While observing the speeches of Obama, we see him as possessing the first and foremost quality of an eloquent orator as mentioned earlier. Another notable feature of Obama is that he is always energetic and confident during his speeches that the long schedules or programs never did tire him. One dominant feature found in Obama’s speech is his ability to pause wherever necessary and resume the speech after observing or studying the audience. His style is identifiable when he began his Democrat Primary Victory Speech on 3rd June, 2008. The beginning, â€Å"Tonight, after 54 hard-fought contests, our primary season has finally come to an end† (Democrat Primary Victory Speech, 2008) justifies the former statement. Obama could also begin the speeches with striking words, though not often with quotations, and maintain the flow of words tinted with poetical lines. He has enough voice projection and voice modulation that can enchant people to him. To conclude, one can infer tha t Obama possesses the notable features of a good public speaker. An evaluation of McCain’ as a public speaker reveals that he is no less than Obama as a talented orator. He could also raise number of people, though he could not win American Presidency Elections against Obama. The outstanding feature of McCain’s speech is that he was motivational that he tried his best to motivate the audience. His words â€Å"Do not yield. Do not flinch. Stand up. Stand up with our President and fight. Were Americans. Were Americans, and well never surrender. They will† (McCain, 2004) are capable of stirring the minds of the people. Like, Obama, he also would acknowledge that his knowledge was limited, if he was not proficient in a particular topic. During his speeches, he tried to present the root cause of the existing problems in American Society as well as in economy. This is very clear when he said, â€Å"Americas most vital

Factors Effecting Erp Implementation In Smes Management Essay

Factors Effecting Erp Implementation In Smes Management Essay Information systems gained popularity as these automate all management related function that an organisation needed. Large organisations implement ERP information systems that integrate all data and processes together. With increase in popularity of SMEs (Small and Medium Enterprises) and their collaboration with large enterprises, SMEs needed an ERP system which at first can automate all of their business functions and secondly they can work with large enterprises. However their successful implementation in SMEs remains an issue. As SMEs are short of resources and financially weak so they need to install an ERP system successfully so that they can avoid chances of failure. For this reason this research has been conducted to critically analyse success factors of ERP adoption. Case studies will be selected and analysis has been made on them to find out the successful elements of their implementation. At last in conclusion a general frame work will be made to help SMEs to implement ERP system successfully. Background: Today the whole world has become a global village in which organisations are competing with each other to improve their productivity and generate profits. This is not generalised to only large organisations as it has been observed from last decade that small and medium size organisations are also taking part in this race (Chen, 2001). Organisations are moving fast to adopt a package that can help their management and functional needs. They require an Enterprise package that can fulfil their demands. ERP is the solution for the enterprises, in current case for small and medium size organisations. Enterprise Resource Planning (ERP) gained its popularity in 1990 as an integrated application. Its functionality is to integrate different functions together and provide a common database to users and departments, with many advantages more specific to reduced inventory and improved profits. ERP evolution starts in earlier 70s when manufacturing companies were using MPS (Master Production Schedule) technique. Function of this technique was to specify the end or finished product that is required in planning period. This type of technique only did the production and scheduling of final product. Whereas manufacturing organisations required not only final product planning but they also needed planning and scheduling of raw materials associated with that final product. Therefore firms obtained MRP (Material Requirement planning) that can differentiate between final product, its parts and raw material. This technique performed production planning and inventory control in the manufacturing p rocess. Basic functionality of this system was planning and scheduling of manufacturing process. This technique became popular and in 1980s MRP systems were expanded and MRP II was introduced, it was not only production planning technique but it also integrated primary functions like (production, finance and marketing etc) into planning process. Because of this technique popularity and effectiveness in planning and production process organisations tend to move to this technique. In 1990s MRP II was further expanded into ERP (Enterprise Resource Planning). The main difference between ERP and MRP II is that ERP plans and schedule supplier resources by keeping customer service in mind (Chen, 2001 and Gupta, 2000). The purpose of the research is to identify success factors of ERP adoption in SMEs. Researches done in this area were deficient of some of the key points. From last couple of years research has been conducted to critically identify success factors of implementing ERP in SMEs. (Kale et al, 2010) did study in identifying success factors of Indian SMEs and their research was based on both qualitative and quantitative. (Snider et al, 2009) studied on five Canadian SMEs but some of their critical success factors lack cultural issues. (El Sawah et al, 2008) and (Woo, 2007) both did research in SMEs, in which they covered only one country and further they intended to enhance their research by taking more SMEs of different countries. (Woo, 2007) explained in study that if cultural differences were given then considered success factors can be same to case studies in China and case studies of Western organisation. (Doom et al, 2010) used Belgian SMEs to research success factors. (Muscatello et al. 2003) did their research on four US manufacturing companies but the companies they choose were linked to large organisations and had annual revenues more then SMEs .(Loh and Koh, 2004) carried out their research in UK and their target was SMEs, they conducted interviews and distributed questionnaires. Their research is found to be more competent as compared to others but still they did not cover demographic issues.(Yusuf et al, 2004) conducted their research on Rolls Royce and found out answers of few success factors. From above studies it is obvious that most of the work has been done in large organisation and little researches were carried out on SMEs. Although, those studies considered SMEs for the research but covered only one region and were short of justification that how success factors of some specific part of world could be implemented in rest of the world. Key issues in successful implementation of ERP Key issues are the problems that arise during the implementation process. There are lot of problems that can affect ERP implementation process in SMEs which are detailed as below (Chen, 2001). Cost is one of the main issues that can fail ERP implementation. As ERP package requires huge finances and companies fail to successfully implement ERP package so they find it difficult to continue with their project. To choose right ERP package is another issue that SMEs have to take into account before implementation. Hershey Food Corp accounts SAP for their failure so choosing right ERP package is a big issue. ERP in SMEs requires some time complex customization because it focuses mostly on corporate giants. So customization is another big issue that can effect ERP implementation. Another main issue is analysis, which projects are failure and which are successful. Project failure and success all depends on judgment and analysis. Fox Meyer as mentioned below, states that their ERP systems did not fulfil their functionality and they marked that project as failure. It is explained in detail in literature review section. Likewise some enterprises termed their project failure because of cost. Project can be termed as success if they meet these criteria. It should be delivered on time It should meet project cost The project should deliver the functionality which that organisation wants. Research aim and objectives The main aim of this study is to propose a frame work for effective implementation of ERP in SMEs. This requires in depth study of literature review and case studies to critically evaluate success factors. The research will be based on the following research question: What are the key issues and problems being faced in the successful implementation of the ERP in small and medium enterprises (SMEs)? To what extent the ERP software contributes to the success factors in SMEà ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ãƒ ¢Ã¢â‚¬Å¾Ã‚ ¢s? In order to answer the above stated research questions the following stages will have to be achieved: To review and carry out in depth analysis of literature review while focal point will be ERP adoption. Critically analyse and identify success factors from different case studies. Match and analyse success factors of literature review with the case studies Develop a frame work of success factors which can help in implementing ERP successfully for Small and medium size organisations regardless of their region and cultural issues. SMEs case studies will be taken who have generally less level of employees. Case studies will be taken from different regions so that more in depth analysis will be done and cultural and demographic issues will be covered in that. This point is explained in much more detail in method of analysis section. Companies who have successfully implemented ERP application will be considered. Literature review According to (Snider et al, 2009) ERP uses common online database whose functionality is to share common database among users and enterprise functions. ERP is an integrated information system that is composed of information system and managerial thinking. One of its core purposes is to integrate all the dependent and independent information systems together and optimise systems performance. ERP system comprises of a database which is online and shared, an application with an integrated interface which means different interfaces are incorporated into one interface. (AL Mashari et al, 2003). ERP achieved its level of popularity in large manufacturing enterprises in 1990s. Large enterprises implemented it to automate their functions and to integrate all processes and data together. On the other hand as SMEs were getting popularity so after implementing ERP systems in large organisations ERP vendors now moved towards SMEs. There are many factors that can encourage SMEs to accept ERP systems. Poston and Grabski (2001) believed there are certain factors that motivate SMEs to adopt ERP systems: It can reduce cost as computer systems increases the efficiency process It can make decision making process accurate. (Oliver and Romm, 2000) suggested these reasons for ERP adoption in SMEs: Data and processes integration Avoid critical business risk Improvement of ongoing business operations. ERP adoption in SMEs is a challenging task especially when cultural issues arise. Cultural issues can occur at organisational values, means it can impact organisational structure and management or at individual value where it can impact how job works and how employees will conduct themselves if they belong to certain culture. (Straub et al., 2001). Developing countries face many problems when they use western technologies from developed countries. ERP encapsulates best business reusable practices in it. For this reason it became a demanding technology that it can use (Sawah et al, 2008) outlined cultural issue to be an important factor responsible for high demand of ERP in SMEs. With these motivational factors that attract SMEs to adopt ERP there is terrible side of this adoption as well where many ERP enterprises fail to adopt ERP systems. Below mentioned are cases of large enterprises but small and medium size enterprises can learn lesson from them by not to adopt that type of implementation. Fox Meyer Drug, a multi billion pharmaceutical company which files for bankruptcy and they blamed ERP system for their down fall. In its case, problems in ordering system leaded as system generated excessive orders more than demand which lead company to down fall. Renowned companies like Dell scrap their mega expensive project as they found system inflexible for their business. These are not only two examples of ERP failures but many other companies like Hershey, Boeing, Dow chemical etc faced same situation (Chen, 2001). In all these companies ERP systems leaded to failure and this was due to not having proper planning before installation. Above mentioned companies a re all large organisations whereas in case of small and medium size organisations, these can not bear the cost of ERP systems failure. This leads this research to critically analyse and find out the success factors in ERP adoption so that SMEs can avoid these failures. Difference Between SMES and Large enterprises: Significant amount of differences can be noticed between large and SME organisations. SMEs have informal structure and culture, their top management are found to be involved in day to day activities (Mintzberg et al., 2003,) while large organisations have structured departments and processes and their top management is not involved in daily activities (Buonanno et al, 2005). At the same time SMEs have limited resources in terms of research development, finance, human resource with limited clients and operates only in small scale (Kale et al, 2010). Due to these limited resources they find it difficult to implement projects that can be reengineered (Mc Adam, 2002). Besides these limited resources they are generating profit very well and for this reason many multinational companies in recent years collaborated with SMEs which have ERP systems installed in them. This collaboration made SMEs to adopt ERP package so that they can operate in parallel with these organisations (Rao, 2000). The major factor which can affect SMEs more as compared to large organisation is the cost as their limited resources donà ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ãƒ ¢Ã¢â‚¬Å¾Ã‚ ¢t allow them to bear high cost of implementation. This is one of the main reasons that SMEs do not want implementation to be unsuccessful. Large organisation can somehow bear the cost as large number of stakeholders bank credits etc but SMEs do not have enough resources. (Mabert et al, 2003). This research is conducted so that it can help SMEs to implement ERP successfully. Proposed research method Most of the researches conducted are in large organisations and only few of them were for SMEs. Out of these researches some used only one case study while some used different case studies and their research method remained different as well because they used questionnaires and interviews to find out success factors. After brain storming and critically analysing previous literature review I decided to use the case study approach. For this reason I decided to identify critical success factors in SME while using multiple case studies. (Stuart et al, 2002) suggested that using case study is the best approach when previous research does not find to be inline with new context while taking multiple case studies can provide even more in depth analysis and portray clear picture of critical analysis(Snider et al, 2009). In case of our research qualitative analysis will be used. First thorough literature review will be studied by means of online journals, electronic books etc. It will help to find previous critical success factors of ERP adoption in SMEs. To give practical edge to research eight different case studies will be searched and from them critically analysis will be done to find out success factors of successfully implementing ERP project. These case studies are selected with relevance to the project title and literature review. They will provide in depth analysis of ERP adoption success factors. With the help of literature review and case studies a framework will be formed of successfully implementing ERP project. Method of analysis For this research case study analysis will be used. Data will be collected from previous research that has been done in this sector and also from small and medium size enterprises that have implemented their ERP application successfully. Case studies will be collected from different parts of the world so that no demographic issues can affect our final framework of success full factors. Then final analysis will be done in between success factors of United Kingdom and rest of the world case studies to observe how much variation is there if different regions are selected. This will be the final analysis and framework of the critical success factors. Research Limitations: This study is limited to small and medium size organisations and in some cases some arguments can be taken from the large organization in order to clarify them. This research is self explanatory as it focuses in ERP adoption system of SMEs. In addition to this study concludes with the framework of ERP critical success factors which if SMEs follows can lead their implementation to success. A provisional Timetable Gantt Chart